Job Details

  • Title: Research Scientist
  • Code: RCI-12161
  • Location: South San Francisco California (CA) 94080
  • Posted Date: 02/13/2020
  • Duration: 6 Months
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  Job Description

Individual contributor to join Clinical Immunology and Bioanalysis within Clinical Pharmacology and Safety Sciences organization supporting clinical and pre-clinical PK/PD and non-clinical toxicology studies.

  • Development, validation/qualification of quantitative mass spectrometry assays to support pharmacokinetic/toxicokinetic/pharmacodynamic analyses in variety biological matrices as well sample analysis
  • Utilize mass spectrometry for detection and quantification of therapeutic peptides and antibodies, including ADCs, small molecules and various biomarkers (proteins, lipids, metabolites)
  • Adhere to established Standard Operating Procedures and contribute to validation protocols, reports and bioanalytical reports
  • Demonstrate competency in troubleshooting, optimization and implementation of challenging and innovative LC-MS/MS assays
Qualifications
  • B.S. in Chemistry, Biochemistry, Pharmaceutical Sciences or other related major with 5-8 years of relevant experience OR M.S. in Chemistry, Biochemistry, Pharmaceutical Sciences or other related major with 2-5 years of relevant experience OR Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences or other related major with 0-2 years of relevant experience
  • Strong background in analytical biochemistry/chemistry with emphasis on mass spectrometric bioanalysis of biotherapeutics (peptides, antibodies, ADCs), small molecules, biomarkers (proteins, lipids, metabolites)
  • Hands-on experience with chromatographic separation of various analytes by LC and characterization and quantification by MS or MS/MS
  • Significant experience in method development and troubleshooting
  • Proficiency with mass spectrometry software as well as spreadsheet, word processing, and graphical computer programs
  • Good organizational, documentation and technical writing skills
  • Good command of English (written and oral)
  • Strong communication and interpersonal skills
Desirable Requirements
  • Industry experience
  • Experience with automation
  • Small/large-molecule mass spectrometry experience
  • Familiarity with basic pharmacokinetic data analyses
  • Familiarity with metabolite identification and profiling studies
  • Knowledge of chromatographic assay validation guidelines and GLP regulations