Job Details

  • Title: Research Associate
  • Code: RCI-36994-1
  • Location: Seattle Washington (WA) 98109
  • Posted Date: 04/06/2021
  • Duration: 6 Months

  Job Description

Actual Job Title: Research Associate

Duration: 6 Months

Typical Work Hours: Mon-Thur 8am-5pm

Weekend/OT: Frequent work required on Sundays during COVID capacity restrictions (some flexibility to set 40hr schedule)


Mix of onsite and remote work

  • Client is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives.
  • Our purpose as a company is to discover and develop therapies that will change the course of human health.
  • We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than
  • 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
  • The Research Associate will join our viral vector process development group supporting process development, production and characterization of viral vectors, which are key intermediates in the
  • CAR-T drug product. The candidate will run cell-based assays using
  • Jurkat cells as a surrogate method to vector infectivity. Additionally, this candidate will provide process development support to current programs and advance our capabilities in vector production.

Responsibilities:

  • Hands-on experimental work in running a Jurkat cell-based assay.
  • Method includes culturing cells, staining, and flow cytometry for quantification
  • Hands-on experimental work in the development and optimization of upstream (cell culture and transfection conditions) and downstream
  • (Clarification, tangential flow filtration, chromatography) unit operations for viral vector production
  • Support the process development program for next-generation viral vector manufacturing platforms
  • Assist in the planning and design of experiments, execution and independent analysis of data
  • Summarize and present scientific data, communicate progress to project teams
  • Maintain proper documentation of experimental results.
  • Support process transfer, development and manufacturing at external CMOs

Basic Qualifications:

  • BS. in Engineering, Virology, Biology, Biochemistry, or related discipline
  • 0-2 years of industry experience in process development
  • Independently motivated with the ability to multi-task, troubleshoot, problem-solve, and work in teams
  • Ability to communicate clearly and concisely through oral presentation and technical writing

Preferred Qualifications:

  • Experience in mammalian cell culture, transfection, harvest and purification of biological products
  • Experience in downstream process development using equipment such as the AKTA Avant
  • Working knowledge of chromatography, UF/DF, and normal flow filtration operations
  • Hands-on purification experience with lentivirus and ability to cross train and support upstream operations
  • Experience with general analytical protocols (e.g. ELISA, qPCR, flow cytometry, etc.) and ability to operate associated analytical equipment and interpret results
  • Process transfer and cGMP manufacturing experience