Job Details

Description:

Manager is looking for someone that has experience with high content imaging and analysis work.

Biologist III/IV- ADC Platform Biology

Description

• Client has an opening for an Biologist III/IV contract position within the Antibody Drug Conjugate (ADC) Platform Team at our Bioresearch Center in Worcester, MA.
• The ADC group within DDST collaborates with drug discovery project teams across all Client therapeutic areas including Oncology and Immunology.
• The ideal candidate will effectively work to collaborate with chemists, biologists and pharmacologists to characterize large and small molecules for ADC development. 

Key Responsibilities:

• Design, optimize, and execute high content cellular imaging assays using genomic manipulations techniques, small or large molecules to study cellular trafficking and pathway biology
• Practical experience with designing and executing cellular assays on high content imaging platforms, data analysis and visualization
• Excellent computer skills and a good understanding of basic image analysis software
• Experienced with working with 2D and 3D in-vitro model systems
• Experienced with low and HTS screening methods
• Experience with designing Co-Culture model systems
• Experienced with liquid handling automation systems
• Experienced with trouble shooting in-vitro assays and validating in-vitro assays
• Experienced with protocol write-ups
• Experienced with corelating target modulation with phenotype while screening or characterizing large or small molecules
• Work collaboratively with project teams to deliver targets across portfolio
• Demonstrate scientific excellence, work ethic, and dedication to team and project goals
• Work collaboratively in a matrix with project teams and members of the Biologics Group to drive innovation and deliver novel therapies to patients
• Develop productive collaborations and communication with other groups across therapeutic areas

Basic Qualifications:

• Bachelor’s degree in related discipline with 5 or more years of experience and a BS/MS in Biology or Biochemistry
• Experienced screening large and small molecules (reporter assays, proliferation and cytokine release)
• Experience executing antibody internalization experiments is a plus
• Experience with transfections and generating transient and stable cell lines
• Experience culturing adherent, suspension and primary cells
• Proficiency in performing flow cytometry and ELISA experiments
• Experience with performing qPCR and automated western blot analysis
• Experience working with high throughput laboratory workflows and instruments such MACsQuant, FACS Canto, Microbeta, Wes, ImageXpress confocal, Amnis Imagestream, Via7 (taqman) and Spectramax plate readers.
• Experience documenting experimental methods and results into BIOELN
• Ability to summarize and present results to project teams 

MUST HAVE:

• MS in related discipline
• 3 -5 years industry/lab experience
• High Content Imaging (Florescent Microscopy, Cellular Staining, Imaging analysis etc.)

NICE TO HAVE / NOT REQUIRED:

• Cell Line Development
• Loss/Gain function
• Screen genetic modifiers

Significant Work Activities and Conditions Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)