Job Details

  • Title: Biologist
  • Code: RCI-17938
  • Location: Worcester, MA 01604
  • Posted Date: 05/13/2022
  • Duration: 12 Months
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  Job Description

Description:

Manager is looking for someone that has experience with high content imaging and analysis work.

Biologist III/IV- ADC Platform Biology

Description

  • Client has an opening for an Biologist III/IV contract position within the Antibody Drug Conjugate (ADC) Platform Team at our Bioresearch Center in Worcester, MA.
  • The ADC group within DDST collaborates with drug discovery project teams across all Client therapeutic areas including Oncology and Immunology.
  • The ideal candidate will effectively work to collaborate with chemists, biologists and pharmacologists to characterize large and small molecules for ADC development. 

Key Responsibilities:

  • Design, optimize, and execute high content cellular imaging assays using genomic manipulations techniques, small or large molecules to study cellular trafficking and pathway biology
  • Practical experience with designing and executing cellular assays on high content imaging platforms, data analysis and visualization
  • Excellent computer skills and a good understanding of basic image analysis software
  • Experienced with working with 2D and 3D in-vitro model systems
  • Experienced with low and HTS screening methods
  • Experience with designing Co-Culture model systems
  • Experienced with liquid handling automation systems
  • Experienced with trouble shooting in-vitro assays and validating in-vitro assays
  • Experienced with protocol write-ups
  • Experienced with corelating target modulation with phenotype while screening or characterizing large or small molecules
  • Work collaboratively with project teams to deliver targets across portfolio
  • Demonstrate scientific excellence, work ethic, and dedication to team and project goals
  • Work collaboratively in a matrix with project teams and members of the Biologics Group to drive innovation and deliver novel therapies to patients
  • Develop productive collaborations and communication with other groups across therapeutic areas

Basic Qualifications:

  • Bachelor’s degree in related discipline with 5 or more years of experience and a BS/MS in Biology or Biochemistry
  • Experienced screening large and small molecules (reporter assays, proliferation and cytokine release)
  • Experience executing antibody internalization experiments is a plus
  • Experience with transfections and generating transient and stable cell lines
  • Experience culturing adherent, suspension and primary cells
  • Proficiency in performing flow cytometry and ELISA experiments
  • Experience with performing qPCR and automated western blot analysis
  • Experience working with high throughput laboratory workflows and instruments such MACsQuant, FACS Canto, Microbeta, Wes, ImageXpress confocal, Amnis Imagestream, Via7 (taqman) and Spectramax plate readers.
  • Experience documenting experimental methods and results into BIOELN
  • Ability to summarize and present results to project teams 

MUST HAVE:

  • MS in related discipline
  • 3 -5 years industry/lab experience
  • High Content Imaging (Florescent Microscopy, Cellular Staining, Imaging analysis etc.)

NICE TO HAVE / NOT REQUIRED:

  • Cell Line Development
  • Loss/Gain function
  • Screen genetic modifiers

Significant Work Activities and Conditions Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)